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The group heads to the House, but John pursues them and only Margot and Jules make it there. To escape back to the real world, they must face their greatest fears.
Margot flees from John when he turns violent. Meanwhile, JD rejoins the group, and Jules begins to lose memories of her childhood.
The cannibal John follows Margot home and tries to make a deal with her so he can stay in the real world. Meanwhile, Jules discovers that she's lost the memories of her mother, and Corinne returns home to see the memory-cannibal wearing her dead husband's face.
Inspired by Brian Russell's Creepypasta tale, Channel Zero: No-End House tells the story of a young woman named Margot Sleator who visits the No-End House, a bizarre house of horrors that consists of a series of increasingly disturbing rooms. When she returns home, Margot realizes everything has changed.