A dying Spanish nobleman asks Flint to impersonate Don Alvarado to claim the inheritance for the rest of his family. This brings Flint into contact with the men who murdered the nobleman.

Dissatisfied with Charley Wooster, Hale and Hawks push for a new cook - a Chinese cook named Ah Chong.

Flint discovers four survivors of an Indian massacre. Despite the ordeal they've survived, they're still unaware of the danger ahead and don't know whether to trust Flint. Complicating matters, one member of the group works against Flint. 

After losing one of her children in an accident, a woman becomes bitterly resentful of the wagon train and plans to turn back east, while her husband wishes to continue west. Hale, in an effort to persuade her to continue, tells her the story of his own trip west with his family and the ensuing tragedy.

An Italian immigrant couple needs help in transporting water for their grapevines to California. Unfortunately, the two men who offer the use of their wagon plan to steal the treasure they've heard the immigrants are carrying in return for their services.

Flint visits Eleanor Culhane, his former love interest who subsequently married a notorious gunman. Towns people avoid her. Believing her husband had been dead for years, Flint begins seeing her, when her husband returns. Flint realizes there is another side to Eleanor that he was unaware of as well.

Jim Bridger, who became Flint's father after his parents died, arrives at the wagon train. Flint is delighted until he realizes Bridger is working as a scout for an Army general who commandeers the train to save troops trapped by Utes.

Will Santee, his mother, and his younger sister join the wagon train under a false surname after many towns forced them out due to the terrible actions of one family member.

With his clever tall tales, old prospector Henry Shannon talks Charlie Wooster into coming with him to search for a gold mine. When Hawks finds out about this, he rides out after the two men, along with Shannon's grandson Duke. Also following the old men are three men who hope to grab the gold for themselves.

Polish immigrant Joe Muharich tries to befriend and hopefully straighten out Johnny Kamen, a brash young man who doesn't take well to anyone giving orders to him.

A blind man, his sister and young son meet up with the wagon train on the trail; they are trying to find a train that will let them travel to California; Saul is a qualified doctor and has hopes of starting a blind school.

Charlie Wooster is smitten by actress Nellie Jefferson, when she joins the train. Not so with others, who tire of her incessant demands for special treatment. Meanwhile an obsessed man from her past is following her, talking about how she will meet her fate like the biblical Jezebel

Tiburcio Mendez and his group of Californios stop the wagon train because they want to keep settlers out. A judge traveling with the train believes a peaceful resolution is possible, but not everyone wants peace.

Flint returns to the wagon train camp to announce that their company has appointed Jud Benedict as their new wagon master, and it isn't good news. Flint McCullough then offers the position to retired wagon master Chris Hale.

A married couple use the wife's innocent face and winning way with children to gain the trust of their companions on the wagon train so that they won't be suspected when the husband pulls off a bank robbery nearby.

Flint brings stranded woman Rheba Polke and her son to the train. When her husband Jed Polke returns with help, many recognize him from the Macon, Georgia Andersonville Prison (Confederate prisoner-of-war camp) where prisoners were planning an escape. Polke had turned their escape attempt in to the authorities. They have sworn to kill Polke.

The leaders of the wagon train are taken aback when they see a woman asking to join the wagon train who is the twin of Major Adams one and only love who died in his arms.

Looking forward to some time off, Flint heads towards the town of Monument but runs into an old man and some kids whose parents were just massacred by Mescalero Apaches. The children are running low on supplies especially milk for the baby.

A dying soldier asks his old friend Ruddy Blaine to bring his daughter Penelope to him before he expires.

The story of the women of the wagon train and the unforgiving prairie through which they pass. Who will endure, and who will give up? Who will live, and who will die?

Bill and Major Adams plan on going hunting with a friend but when he is not home they suspect a renegade party of Cheyenne who have broken the peace treaty and the wagon train may be their next target.

Retired Captain Sam Elder and ten boys join the wagon train on their way to California. The boys are orphans of soldiers that fought and died under Elder in the war. he hopes to open a military academy. Hitching a ride was all he thought he was involving the boys with until he meets one man on the train with a secret resentment.

Quaker schoolteacher Patience Miller heads to the Arapaho nation on the wagon train when her husband is killed by the Comanches. Patience is confronted immediately by Chief Spotted Horse and braves but they back off when they see her red hair calling her a medicine woman. She meets the Chief and his willingness to fight another Indian nation puts her right in the middle of each tribe's pride and customs.

Wounded Bill Strode arrives in camp looking for Flint. Strode, who saved Flint's life in Abilene, asks Flint to help him get to Fort Kearny. Flint learns the itchy Strode is being hunted by bounty hunter Earl Packer and Strode has changed.

Flint hires drunk Jeff Durant to drive a wagon on the train. It turns out that Jeff is Jeremy Dow, who supposedly died a heroic death years ago and whose family is on the train.

Roger Bigelow turns to the ministry with his father's help when he realizes what he might become without it. He gets the chance to help someone else on the wrong path but Major Adams is not sure the reverend is helping the right person.

Colonel Buckner mistakenly wipes out a Comanche Indian village of women and children, and now Comanche braves are looking for revenge.

Gabe Henry and his son have been sorely missing the female touch over five years now. Finding a wife during a stopover is his top priority but his choice is known to Major Adams and he does not approve.

Flint discovers a badly wounded waitress on the range and takes her to a doctor. He learns that the evil town's owner wants to hang her without trial because he suspects she murdered his son.

Dr. Craven feels he can't perform surgery any longer. When he joins the wagon train and his services are desperately needed, he realizes he may be wrong after Major Adams gives him a history lesson.

Flint, Hawks and Wooster are leading a small group of wagons split off the main train to the Dakotas. When the rains won't stop the wagon train has to travel through a Sioux Indian burial ground.

After Cathy Eckhart is murdered, apparently by Indians, Seth has each of the witnesses testify... and their stories will determine if Ben Harness lives or dies since he's been convicted of the murder of Cathy's father.

Flint takes three men to investigate Haunted Mountain, and finds a lost tribe of Aztecs.

Bill is forced to team up with Jose Morales and his band of Mescaleros when Apaches threaten to kill them all.

Flint faces execution after killing a supposed horse thief who turns out to be the local town's mayor... and the husband of his childhood friend.

An arrogant British colonel joins the train and starts a feud with an Irish family... and then endangers the train when he insults a Cherokee chief.

Horace Best, Seth's "cousin", undermines the wagon train by making better deals to build his own train. Now all he has to do is get it to California.

While preparing to return to St. Joseph, the men read the story "Wagon Ho" written and printed by Samuel T. Evans about his trip as a naive young Irishman headed west and his experiences and adventure on the trail.