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The bus takes Ms. Frizzle and the class deep inside Arnold's cousin Janet to learn why our genes makes us look, act and feel the way we do.
Every person and animal poops. But the class isn't convinced that this so-called "brown gold" is as valuable as DA's famous inventor uncle says it is.
A field trip to the center of the sun takes a dangerous detour when the school's safety-conscious principal, Mr. Ruhle, tags along.