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Cesare loses his lover and his daughter, leading to a painful defeat, and Lucrezia's betrothal becomes politically and emotionally complex.
Outside of Italy, rebellion stirs and the Cardinals fear they'll lose their power, while plans begin for Lucrezia's next marriage.
Cesare's renegade generals mount a rebellion against him, while those close to Rodrigo conspire against him, all on the eve of Lucrezia's wedding.