Cesare's ultimate judgment is realized while Lucrezia struggles to make sense of her family's history and its future.

Cesare is brought to La Mancha and goes on trial before the Inquisition, while Lucrezia must use extreme measures to save her marriage.

Cesare stands trial for treason against the Holy See and the Ten Commandments, with his old friend Niccolo Machiavelli as prosecutor.

With a new pope crowned and order breaking down, Cesare finds himself with more and stronger enemies than ever.

Rodrigo's death sets chaos in motion on many fronts and forces Cesare to practice his most sophisticated politics yet as stakes are raised.

Lucrezia meets her new family with mixed results, while at home a malaria outbreak has historic consequences for the Borgias.

Cesare's renegade generals mount a rebellion against him, while those close to Rodrigo conspire against him, all on the eve of Lucrezia's wedding.

Cesare loses his lover and his daughter, leading to a painful defeat, and Lucrezia's betrothal becomes politically and emotionally complex.

Outside of Italy, rebellion stirs and the Cardinals fear they'll lose their power, while plans begin for Lucrezia's next marriage.

While Rodrigo engages in delicate politics, Leonardo da Vinci offers Cesare a powerful weapon and murder visits the Borgia family.

When one of his commanders captures a city without authorization, Cesare must appease a ruler. Lucrezia's son suffers a potentially mortal fall.

Cesare's new mistress could trigger a diplomatic indecent, and public allegations of debauchery are made against the Borgia family.

Cesare awaits an answer to his ultimatum to Florence, while Rodrigo is stricken ill and Lucrezia becomes embroiled in sexual politics.

Rodrigo returns from his monastery and makes Lucrezia First Counselor, while Cesare remains on a military campaign to subjugate the rebel provinces.