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Lucrezia meets her new family with mixed results, while at home a malaria outbreak has historic consequences for the Borgias.
Cesare's renegade generals mount a rebellion against him, while those close to Rodrigo conspire against him, all on the eve of Lucrezia's wedding.
Rodrigo's death sets chaos in motion on many fronts and forces Cesare to practice his most sophisticated politics yet as stakes are raised.