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Sam moves closer to his destiny while Mohamad tries to free himself from imprisonment. Axel escorts San Francisco survivors to Denver. Ivory and Scab take control of the Daywalker horde.
Vanessa has a final showdown with the Second Elder in San Francisco; in Denver, Flesh, Doc, Julius and Jolene learn that even in a Safe-Zone, life isn't easy.
On a distant island, Vanessa and Scarlett battle the Third Elder. Vanessa makes a choice about her path forward, one that Scarlett does not agree with.
This season continues to follow Vanessa Van Helsing and her band of heroes as they fight to reclaim the world after vampires took over during ‘The Rising'.