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This season continues to follow Vanessa Van Helsing and her band of heroes as they fight to reclaim the world after vampires took over during ‘The Rising'.
Vanessa and Sam face off to find the Last Elder, with Scarlett, Axel and Mohamad caught in the crossfire; Julius fights the Sisterhood; Doc unlocks the secrets in the Dark One's blood.
Scarlett is reunited with Axel but he is badly injured before they can find Vanessa; a mysterious man helps them find their way; Flesh and Jolene are fugitives on the run from Blaktek.
In his hometown, Axel fights both his tragic past and a vicious pack of Daywalkers; Sam can't find Mohamad and takes his anger out on Chad and Mike.
Vanessa, trapped in an abandoned slaughterhouse, wrestles between the light and dark sides of her own self before she can move forward on her path to find the Final Elder.
Doc and Jolene clash with Denver authorities over the repellent. Flesh chooses to face his past. Axel struggles with leaving Scarlett behind. Ivory and the Sisterhood infiltrate Denver.
On a distant island, Vanessa and Scarlett battle the Third Elder. Vanessa makes a choice about her path forward, one that Scarlett does not agree with.
Sam moves closer to his destiny while Mohamad tries to free himself from imprisonment. Axel escorts San Francisco survivors to Denver. Ivory and Scab take control of the Daywalker horde.
Vanessa has a final showdown with the Second Elder in San Francisco; in Denver, Flesh, Doc, Julius and Jolene learn that even in a Safe-Zone, life isn't easy.
In San Francisco, Vanessa, Scarlett and Axel find and battle against the Second Elder's forces; in Denver, Flesh, Doc, Julius and Jolene rejoin American civilization as best they can.
Sam comes to realize his dark destiny and tries to groom Mohamad to be a worthy partner. Scab and Ivory are bestowed Daywalker powers and return home to find the Sisterhood in ruins.
Vanessa relives the memories of her ancestor, Lily Van Helsing, in Colonial Hong Kong; there, she learns to control her dark side and fights the B'ah, the second vampire Elder.
To find its totem, the First Elder brings Vanessa, Scarlett and Axel to an abandoned insane asylum protected by powerful vampires, where they discover the legacy of a long dead Van Helsing relative.
Vanessa is once again resurrected and must confront her family's legacy; Axel, Scarlett and the others fend off Blak Tek's forces, who hope to add Scarlett to their list of lab rats.
In the fifth and final season of Van Helsing, Vanessa, Violet and Jack will risk everything to finally bring an end to the Dark One once and for all. The Van Helsings must figure out ways to escape and evade the various obstacles in their path to prevent them from their mission, leading to an epic final showdown between the Van Helsings and the Dark One. Who will win the battle between light and dark?
This season, the first of four vampire elders has been freed and legend has it that when their four Totems are combined the Dark One will be resurrected. Now it's a race against time as Vanessa and her ragtag group of heroes faces off against the forces of darkness.
This season continues to follow Vanessa Van Helsing and her band of heroes as they fight to reclaim the world after vampires took over during ‘The Rising'.
Vanessa and the other survivors discover old alliances have crumbled, and new connections expose long-buried secrets about The Rising, the Van Helsing heritage and the survival of humankind itself.