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Tom and Jerry are out fishing when they discover the elusive Butchfish, a half-cat, half-fish that wants to eat Jerry while Tom wants to eat it.
When a hungry monkey gets hold of Mrs. Two-Shoes' gumdrop-filled purse, Tom risks bodily harm to retrieve it, while Jerry does what he can to make sure the monkey gets fed -- even if that means riding in a car with a primate behind the wheel!
In the Australian Outback, Jerry is adopted by a very protective momma kangaroo, whom Tom must overcome if he's to get his mouse.
Tom visits the African veldt to see his lion relatives and give them Jerry as a present, but the lions would rather eat Tom!
Tom tries to win the affection of a lady cat by giving her Jerry, but when she's mean to him, he wants his mouse back, and goes to musical lengths to get him.
Tom attempts to guard a trendy music store, but DJ Jerry keeps on pilfering the merchandise for his "Hole in the Wall" dance club, setting up a showdown.
In 1849, at Sutter's Mill in California, Tom and Butch try to steal Jerry's gold strike.
Butch indoctrinates Tom into the League of Cats, an organization that helps cats catch mice, but they get into a musical rumble with Jerry's new group, the League of Mice!
Tom and Jerry plunge over a waterfall into a spooky and menacing forest, where they meet a trapped Butch -- Now, the three try to escape back to the real world.
Tom's daydream of being a crime-fighting super-cat becomes a reality when a chase with Jerry leads the pair into a real crime fighter's lair.