As Dr. Marcus Andrews vows to help a good Samaritan who was injured while stopping a sexual assault, Dr. Audrey Lim faces a difficult decision when a young patient's parents suspect that Dr. Neil Melendez made a mistake. Meanwhile, Dr. Shaun Murphy fields advice following his disastrous date with Dr. Carly Lever; and Dr. Claire Browne gets a surprise visit from her mother.

As a conspiracy theorist questions Dr. Neil Melendez's of his liver damage, Dr. Claire Brown treats a woman whose inability to feel pain is threatening both her marriage and her life. Meanwhile, Dr. Shaun Murphy and Dr. Aaron Glassman each face crises in their romantic relationships.