Following what he believes was a disastrous first date with Carly, Dr. Shaun Murphy proposes a radical surgery to save a newlywed woman's life. Meanwhile, after the new chief of surgery, Dr. Audrey Lim, announces that the residents can lead surgeries, Dr. Morgan Reznick and Dr. Alex Park compete for the chance to operate on an elderly patient who has been diagnosed with cancer.

Dr. Claire Brown faces complications at home and at work as she prepares to lead her first surgery. Meanwhile, a sports fishing accident challenges the rest of the staff as they look to treat the fisherman's injuries without damaging his prize catch.