When Dr. Shaun Murphy makes an emotional confession, the result may not be as desired. Meanwhile, he becomes obsessed with performing an autopsy on a Jane Doe, which challenges his relationships at the hospital; and Dr. Claire Browne, Dr. Morgan Reznick and Dr. Marcus Andrews treat a male college student with a mysterious split personality disorder.

Dr. Claire Browne and Dr. Shaun Murphy treat a patient with a rare form of dwarfism. Meanwhile, Dr. Morgan Reznick, Dr. Audrey Lim and Dr. Alex Park treat a young man who had both arms torn off in a previous farming accident; and Shaun reacts to an emotional situation.