A patient with a mysterious and undiagnosed illness that has baffled other doctors for years forces Dr. Shaun Murphy and the team to take some big risks. Meanwhile, Dr. Claire Brown and Dr. Neil Melendez continue to cautiously navigate their feelings for each other as colleagues and friends.

The city of San Jose is rocked by a massive earthquake that puts the staff of St. Bonaventure Hospital on high alert as they race to assess the damage and account for the safety of their colleagues and friends. Meanwhile, Dr. Neil Melendez and Dr. Aaron Glassman are attending a charity event when their lives are threatened by the earthquake.