Dr. Shaun Murphy and Dr. Morgan Reznik grapple with a terminal cancer patient who is determined to live the last few months of his life without inhibition. Meanwhile, Dr. Reznik must confront her relationship with her mother when she comes in for a third opinion from Dr. Glassman; and Shaun and Carly's relationship reaches a new level of intimacy.

Despite everyone else's doubts, Shaun is hopeful that Carly is truly fine with his friendship with Lea. The team treats a young boy born without a fully formed trachea and unable to speak, and who may be a good candidate for an experimental procedure.