After Dr. Shaun Murphy treats a patient who is a social influencer, he deals with unwanted attention. Meanwhile, the team treats a woman who is in abdominal distress after an at-home fecal transplant; and Dr. Carly Lever's efforts to separate Shaun from Lea are challenged.

When Dr. Shaun Murphy makes an emotional confession, the result may not be as desired. Meanwhile, he becomes obsessed with performing an autopsy on a Jane Doe, which challenges his relationships at the hospital; and Dr. Claire Browne, Dr. Morgan Reznick and Dr. Marcus Andrews treat a male college student with a mysterious split personality disorder.