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First place in the AFC East is on the line as the Patriots (8-4) visit the Bills (7-4). New England has won six straight games and is 5-0 on the road in 2021. The defending division champion Bills swept the Pats in 2020 for the first time since 1999.
The Cardinals try to sweep a season series from the Rams for the first time since 2014. Arizona halted an eight-game slide versus Los Angeles with an emphatic 37-20 triumph in Week 4. The Cardinals' James Conner scored two touchdowns in that contest.
