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Surgeons battle to save a patient with an aggressive tumour and a patient whose aorta – the body's biggest artery – could rupture at any moment.
Surgeons attempt a rare and high-risk transplant to transform their 21-year-old patient's life and perform a complex kidney procedure vital for another patient's survival.
Surgeons at NHS Lothian perform high-risk surgery to repair a failing heart and take extreme measures to prevent the return of breast cancer in a young patient.
The new series will be filmed in Edinburgh and The Lothians at some of the region's leading centres of medical excellence - NHS Lothian's The Royal Infirmary, Western General and St. Johns.
With unprecedented access to surgeons, anaesthetists, theatre staff and patients, the series will once again offer a unique insight into to the innovative and experimental surgeries taking place on the frontline of medical science.