The emergency department hosts a family reunion after a woman and her grandmother are admitted together. With Bash's future on the line, he and Dr. Bishop try to save each other. Mags makes a big decision about her career. June makes an unexpected commitment. Theo throws himself into a new opportunity.

Bash's career is threatened, leaving him with a major decision to make. When a toxic father needs a liver transplant, Bash deals with the man's estranged son. While treating a woman having strange reactions to a spider bite, Mags employs a strategy to work alongside Novak. Theo helps a young lupus patient make her dreams come true, and takes steps to rebuild his life. June discovers her father's secret. Dr. Bishop and Claire begin a new chapter.

Mags is surprised when a patient triggers her. Bash treats a woman suffering from Locked-in Syndrome, and the husband whose life revolves around caring for her. Bash takes Amira out of town for a joyful dance recital, where a familiar face surprises them. Dr. Bishop's ambitions for the department lead to consequential staffing changes. June and Dr. Singh's differences get in the way of their work. Theo treats a teen with a rare presentation of Attention Deficit Hyperactivity Disorder (ADHD) and gets a visit from his father.

A city-wide blackout sends the hospital into total darkness. Bash treats a rock climber who fell from a cliff. Dr. Bishop and Bash make a major career decision, putting their futures on the line together. June is finally forced to face her father. Theo goes above and beyond to treat a deaf child, while letting frustration get the best of his spiralling personal life. Claire struggles to find footing in her new role as a nurse practitioner, and Mags pays a visit to a former mentor.

Fighting to save a baby with a heart defect, Mags is flooded by memories of her own health struggles as a child. With his performance still being closely scrutinized, Bash remotely treats a cluster of patients with an undiagnosed illness in Aleppo, while also caring for the victims of a Toronto apartment fire. Dr. Bishop asks Claire for a life-altering favour. Theo's unpredictable decisions start piling-up, and June's professional and personal lives collide.

Bash's past weighs heavily on him as he fights for an emancipated teenager with a failing kidney. Mags treats a baby with a complicated heart condition. Theo is thrown by an asthma patient's brazen mother. After a patient makes waves, Dr. Bishop advises Bash to play it safe, while championing a new initiative in the York Memorial emergency department. June backs Dr. Bishop's proposal for a Trauma OR, sets boundaries with her brother, and tries to get a surgical patient to his wedding.

When treating a young woman with a rapidly progressing health crisis, and an overbearing doctor/father, Bash and Mags have a difference in opinion. Dr. Bishop confides in Bash about a professional dilemma. Theo over-invests in the rocky relationship between his new-parent patients. June puts herself on the line for a sick woman following a gastric bypass, against the advice of a powerful surgeon. Mags makes a big career decision.

Rania and Bash make a difficult decision. Theo is surprised by his unresolved anger while treating a young boy who accidentally ate his parents' cannabis edibles. June's brother, Charles, brings urgent news about their father. Mags decides to broaden her horizons while advocating for a member of the hospital cleaning crew who was injured on the job. Dr. Bishop faces a daunting professional challenge.

Bash helps his undocumented friend Khaled apply for asylum. At the hospital, he treats a couple from India reconciling with their desire to return home. Theo and his charismatic medical student, Jake treat a teenage boy with an eating disorder. Mags gets an unexpected career opportunity but faces self-doubt after her recent setbacks. Dr. Bishop and Claire adjust to new hurdles in their relationship.

Rania and Bash reach a crossroads. Dr. Bishop contends with career limitations. Mags is shaken by a violent encounter. The team treats a family separated by a brutal boating accident. Theo struggles to reach a boy with Sensory Processing Disorder.

Bash turns to his therapist to make sense of some haunting memories. A figure skating duo face a painful reality after an accident on the ice. Mags struggles under Novak's harsh treatment. Dr. Bishop's future is threatened by scrutiny over past actions. Meanwhile, June discovers the challenges that come with ambition, and Theo's marriage faces a crisis.

Bash's reunion with Rania ignites difficult memories, and his patient experiences an apparent miracle. Mags's go-the-extra-mile approach gets unwanted attention from her new boss Novak. June vies for Chief Surgical Resident. Grappling with distance from his own daughters, Theo helps a teenager make life or death decisions for her injured younger sister. Claire studies to become a nurse practitioner.

A bus full of kids crashes and sends the team racing. Bash's life is upended when he is reunited with a woman from his past. With Dr. Bishop still unconscious after his stroke, Mags struggles to find support in her mentor's absence. Theo faces repercussions from his family after taking a full-time job away from home, and June has an important career decision to make.