Animal lover Paul O'Grady returns for a third series of Animal Orphans but he's not off to Africa. For the first time, Paul heads further east, to Borneo. He finds out what is being done to support the survival of endangered species to give an insight into the important work being done by dedicated teams of experts and the challenges they face.

Paul encounters orangutans, turtles, and gibbons amongst others, who are being hand-raised or helped by people. Some of the animals he meets are orphans because of humans. Their parents having been killed when their natural habitat of the rainforest was destroyed to make way for palm crops. Paul gets hands-on straight away, helping to care for and rehabilitate the animals.