Set in the Lancashire village of Ormston in the 1950s, Born and Bred centres on the relationship between city doctor Tom Gilder and his village GP father, Arthur Gilder.

Tom returns to the village he grew up in to help his father, Arthur, bring the cottage hospital into the National Health Service. Their medical methods and generational differences occasionally put them on a collision course & it often takes the effort of the whole village to stop them from killing each other.