Before they can save the world from The Candlemaker, the Doom Patrol must first confront their childhood imaginary friends. Meanwhile, Jane reflects on the first time that Miranda became "primary," and Dorothy must make a fateful choice.

Determined to prove her worth in The Underground, Jane brings Larry to rural Arkansas to help her retrieve an invaluable item. Meanwhile, Niles organizes a special day for Dorothy, who hides a personal development from her declining father. And Cliff gives father/daughter bonding with Clara his best shot, while Rita embraces her superhero status as "The Beekeeper" and Vic is forced to confront the real Roni.

While Niles heads north to find Dorothy's mother, the Doom Patrol embraces their inner morons after receiving a mysterious package.

As Niles and Cliff set out to find a missing Dorothy, Larry is tasked with handling Niles' old research team when the ageless aeronauts return from space.

Dorothy finds a friend in Baby Doll, while Vic looks to win Roni back. With Rita's help, Larry finally tries to break the ice with his family.

When the Dannyzens throw a massive party at Doom Manor to resuscitate Danny the Brick, Dorothy longs to join the festivities and experience life as a grown-up. As the party rages on, Rita asks Flex Mentallo to help unleash her full potential – which has some dangerously racy consequences.

In the wake of a terrifying omen, Niles and Rita enter the interdimensional palace of the infamous Red Jack, who feeds on pain and has taken Larry prisoner. Jane is called to The Underground to receive an ultimatum, while her physical body travels to Florida with Cliff, who's eager to prove he's a good father. Back at the manor, Dorothy's game of hide and seek ends badly.

Cliff, Jane, and Rita pursue Dr. Tyme and his time-altering space mineral – in their reluctant quest to help Niles and Dorothy. At a support group, Vic meets Roni, a feisty military vet who challenges his beliefs. And Larry comes face-to-face with his past at a funeral.

Niles, Jane, Cliff, Rita, Vic and Dorothy are still trapped in miniature-size, weeks after the events of last season. Camped out in Cliff's miniature race-track set up, Dorothy tries to befriend both Cliff and Jane, while Larry does his best to figure out a way to restore everyone to their normal size once again. Meanwhile, Rita asks Vic for help in using her elastic abilities for good, while Jane hides out in the Underground and Niles tries everything to earn forgiveness for his past deeds. In the end though, Niles will have to sacrifice something very precious, by making a bargain with Willoughby Kipling in order to help the team and keep his daughter safe – and the world safe from her imaginary friends.