In season two, as the CIA's fight against terror moves closer to home, Joe (Saldaña), Kaitlyn (Kidman), and Byron (Kelly) enlist a new Lioness operative to infiltrate a previously unknown threat. With pressure mounting from all sides, Joe is forced to confront the profound personal sacrifices she has made as the leader of the Lioness program.The series also stars Dave Annable, Jill Wagner, LaMonica Garrett, James Jordan, Austin Hébert, Jonah Wharton, Thad Luckinbill and Hannah Love Lanier. 

Special Ops: Lioness, inspired by an actual U.S. Military program, follows the life of Joe while she attempts to balance her personal and professional life as the tip of the CIA's spear in the war on terror. The Lioness Program, overseen by Kaitlyn Meade and Donald Westfield, enlists an aggressive Marine Raider named Cruz to operate undercover alongside Joe among the power brokers of State terrorism in the CIA's efforts to thwart the next 9/11.