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The Superior and his men abduct Billy Koenig to get the location of the Darkhold from him. While Coulson and his field team go after Sam, Fitz, Jemma, and Mack deal with the Holden LMD that they captured.
Coulson authorizes a mission to bug Nadeer's office against Talbot's advice, but things go bad. Meanwhile, Holden finds the key to keeping Melinda imprisoned, and Fitz finds out what his friend is up to.
The Superior sends Terrence to trigger Terragenesis in Nadeer, believing that she's an Inhuman. However, they all got an explosive surprise. Meanwhile, Coulson and Mack track down the woman that Aida's appearance was based on and try to use her to find Melinda.
The fourth season of the American television series Agents of S.H.I.E.L.D., based on the Marvel Comics organization S.H.I.E.L.D., follows Phil Coulson and other S.H.I.E.L.D. agents and allies after the signing of the Sokovia Accords.