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Coulson authorizes a mission to bug Nadeer's office against Talbot's advice, but things go bad. Meanwhile, Holden finds the key to keeping Melinda imprisoned, and Fitz finds out what his friend is up to.
After an attempt on Jeffrey's life, Coulson and Mack escort him to safety... and discover the secret of his Inhuman abilities. Meanwhile, Fitz promises the decapitated Aida that he'll try to restore her, and Melinda wakes up in Holden's apartment.
The Superior and his men abduct Billy Koenig to get the location of the Darkhold from him. While Coulson and his field team go after Sam, Fitz, Jemma, and Mack deal with the Holden LMD that they captured.
The fourth season of the American television series Agents of S.H.I.E.L.D., based on the Marvel Comics organization S.H.I.E.L.D., follows Phil Coulson and other S.H.I.E.L.D. agents and allies after the signing of the Sokovia Accords.