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Sheldon feels slighted when Professor Proton seeks advice from Leonard instead of him, and he seeks revenge by befriending a rival science TV host, Bill Nye. Meanwhile, Raj gets jealous when Howard crashes "girls' night".
Sheldon's major scientific breakthrough makes him feel like a fraud. Meanwhile, Howard's romantic gesture to Bernadette causes Penny to step up her game with Leonard.
Leonard tries to keep Sheldon from overreacting when a past mistake comes to light, but Sheldon punishes Leonard by making him walk a mile in his shoes. Meanwhile, Penny confronts Raj's ex-girlfriend, Lucy.
Sheldon and Amy's relationship takes a step forward, Penny makes big decisions in her professional and person life, Raj tries to prosper in the dating world with his newfound ability to talk to women, and Howard treats Bernadette to a very special surprise for the anniversary of their first date.