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Leonard tries to keep Sheldon from overreacting when a past mistake comes to light, but Sheldon punishes Leonard by making him walk a mile in his shoes. Meanwhile, Penny confronts Raj's ex-girlfriend, Lucy.
Sheldon feels slighted when Professor Proton seeks advice from Leonard instead of him, and he seeks revenge by befriending a rival science TV host, Bill Nye. Meanwhile, Raj gets jealous when Howard crashes "girls' night".
Sheldon protests when the gang drags him to Mrs. Wolowitz's house for Thanksgiving. Meanwhile, Penny and Leonard must deal with a mistake from her past.
Sheldon and Amy's relationship takes a step forward, Penny makes big decisions in her professional and person life, Raj tries to prosper in the dating world with his newfound ability to talk to women, and Howard treats Bernadette to a very special surprise for the anniversary of their first date.