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Sheldon protests when the gang drags him to Mrs. Wolowitz's house for Thanksgiving. Meanwhile, Penny and Leonard must deal with a mistake from her past.
Leonard tries to keep Sheldon from overreacting when a past mistake comes to light, but Sheldon punishes Leonard by making him walk a mile in his shoes. Meanwhile, Penny confronts Raj's ex-girlfriend, Lucy.
Leonard and Amy help Sheldon cope with the shame he's feeling after his accidental contribution to science is disproved. Meanwhile, Raj must stay with Howard and Bernadette for a week.
Sheldon and Amy's relationship takes a step forward, Penny makes big decisions in her professional and person life, Raj tries to prosper in the dating world with his newfound ability to talk to women, and Howard treats Bernadette to a very special surprise for the anniversary of their first date.