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Ivy and Kite Man's wedding plans are threatened to be derailed by an overzealous Commissioner Gordon who can't resist a party with all of Gotham's biggest villains; Ivy and Kite Man's best chance at happiness is for Harley to come to the rescue.
Darkseid agrees to give Psycho the world if he brings him the head of Harley Quinn, so Psycho controls Ivy to set her against Harley.
In order to defeat Psycho's army, Harley & Joker need to track down Fables' storybook with the Justice League inside.
Alone on Christmas Eve, Harley reconnects with a now-sane Joker and heads to Wayne Tower, where their dinner is interrupted by an escaped Riddler and ParaDemons.
It's Bachelor/Bachelorette weekend for Ivy and Kite Man.
While Harley & Ivy deal with their post-kiss awkwardness, the President tells Gordon that he must get rid of Harley to put Gotham back on the map.
Acting as a judge, Two Face sentences Harley & Ivy to life in Bane's prison. Meanwhile, Jim Gordon and Batgirl vow to take back the GCPD from Two Face.
When Harley & Ivy spot a seemingly sane Joker, they debate whether people can change – revisiting a flashback about Harleen Quinzel's first day at Arkham.
Bruce Wayne awakens from his coma to find Gotham in shambles. Meanwhile, Two-Face attempts to forge a criminal alliance with Bane, to be the only two Big Bads left in Gotham.
Harley and crew try to infiltrate Mr. Freeze's lair only to become human lab rats for his experiments to find a cure for his cryogenically frozen wife, Nora.
Harley & Ivy team up with Catwoman to steal a museum artifact that's been boobytrapped by Dr. Trap. Meanwhile, Dr. Psycho tries to prove himself as a leader.
Harley & Ivy go undercover as college students to take down Riddler, who's made himself dean of the local university with sinister plans for students.
After Gotham is declared no longer part of the United States, the newly formed Injustice League try to seize control of the city away from Harley.
The fifth season of Harley Quinn finds Harley (Kaley Cuoco) and Ivy (Lake Bell) in a new location: Metropolis! – the home of all things Superman, Lois Lane, and the Daily Planet. Harley and Ivy discover that something sinister is at play and all is not what it seems. Looming threats include Lex Luthor and his sister, Lena Luthor, plus fan-favorite Brainiac. But of course, Harley's crew of misfits and allies will join her on this irreverent journey that takes no prisoners in having fun in the DC sandbox.