Married against their parents' wishes, cousins José Arcadio Buendía and Úrsula Iguarán leave their village behind and embark on a long journey in search of a new home. Accompanied by friends and adventurers, their journey culminates with the founding of a utopian town on the banks of a river of prehistoric stones that they baptize Macondo. Several generations of the Buendía lineage will mark the future of this mythical town, tormented by madness, impossible loves, a bloody and absurd war, and the fear of a terrible curse that condemns them, without hope, to one hundred years of solitude.