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Married against their parents' wishes, cousins José Arcadio Buendía and Úrsula Iguarán leave their village behind and embark on a long journey in search of a new home. Accompanied by friends and adventurers, their journey culminates with the founding of a utopian town on the banks of a river of prehistoric stones that they baptize Macondo. Several generations of the Buendía lineage will mark the future of this mythical town, tormented by madness, impossible loves, a bloody and absurd war, and the fear of a terrible curse that condemns them, without hope, to one hundred years of solitude.
Years later, when Aureliano reveals his war plans for Macondo, a heartbroken Ursula comes to a shocking realization about her family.
Arcadio enforces liberal rule in Macondo, while Aureliano attempts to free a colonel from the conservatives. The looming threat of war finally arrives.
José Arcadio Jr. returns, shocking everyone with his wild nature, specially Rebecca. Amid political unrest, Aureliano becomes a revolutionary leader.
Arcadio becomes the school's principal, and Pilar has significant news for Aureliano. Remedios fills the Buendía home with joy — until tragedy strikes.
A new mayor and his family settle in Macondo. Aureliano experiences love for the first time, while a death drives José Arcadio into madness.
An odd girl brings a delirious sickness to Macondo. José Arcadio becomes fascinated by Melquiades' camera. Rebeca and Amaranta vie for Pietro's attention.
Aureliano has visions of a war, while José Arcadio Jr. meets a woman. José Arcadio's alchemy obsession pushes Ursula to find a way to support the family.
Fearing a ghost and a curse, Úrsula and José Arcadio leave their town to establish a new home along a few others, braving a journey through tough terrain.
Following the signing of the armistice, peace still does not reach Macondo. Fearful of Colonel Aureliano Buendía's threats, the Conservatives plot an assassination attempt that - by a twist of fate - brings Fernanda del Carpio from Bogotá to the town. When she marries Aureliano Segundo, one of the bastard Arcadio's twin sons, she gives Úrsula Iguarán her first legitimate heirs.
Meanwhile, José Arcadio Segundo, the other twin, will accomplish the patriarch's wild dreams of connecting Macondo with the world. The railroad's arrival opens the doors to the banana company, which unleashes the town's downfall and ultimately fulfills Úrsula Iguarán's curse: for the lineage condemned to one hundred years of solitude were not granted a second opportunity on earth.
Married against their parents' wishes, cousins José Arcadio Buendía and Úrsula Iguarán leave their village behind and embark on a long journey in search of a new home. Accompanied by friends and adventurers, their journey culminates with the founding of a utopian town on the banks of a river of prehistoric stones that they baptize Macondo. Several generations of the Buendía lineage will mark the future of this mythical town, tormented by madness, impossible loves, a bloody and absurd war, and the fear of a terrible curse that condemns them, without hope, to one hundred years of solitude.