Dr. K and her staff are faced with many difficult cases this week. A pot-bellied pig comes into the clinic with an obstruction in her stomach that leads to emergency surgery. A salomon boa presents with a bad respiratory infection that can lead to death if not treated properly. A black swan is rushed in after being run over by a car. The swan must have surgery but may not survive due to the severity of the injury. Dr. Thielen sadly has to diagnose a 5-year-old Ferret with insulinoma, which is a fatal pancreatic cancer that occurs in over 60 percent of the species. And an egg-bound turtle must lay 12 eggs to avoid surgery.

It is sink or swim as Dr. K tries to solve mobility issues for two goldfish. A severe macaw is brought in with a serious bite wound to the foot, caused by a bigger bird. A rabbit presents with a large amount of fluid in the abdomen and the exploratory surgery reveals a shocking result. Dr. K treats a tiny yellow-bellied slider that may have pneumonia, while Dr. Thielen treats a ferret with a large tumor on her tail.

It's a race against time as Dr. K treats a pet goat with kidney stones, that must undergo two surgeries. Meanwhile, a baby macaw comes in with a genetic bone disorder that makes it unable to stand. Dr. K decides to perform a risky orthopedic surgery to reform the bones, allowing the bird to stand. And Dr. K performs an unusual procedure for a guinea pig's eye injury.

Dr. K's day kicks off with an emergency when a bleeding cockatiel comes into the clinic. Dr. Thielen sees three animals in one appointment including a skunk that needs to be spayed and two panther chameleons in for a wellness check. Then Dr. K finds a litany of ailments in a 9-year-old ferret and must manage its care and quality of life. Meanwhile, a quaker parakeet's owners are concerned about a tumor, only to find out that the bird is so obese that it must lose a third of its body weight and see a heart specialist. Dr. Thielen tries to relieve a gerbil of an abscess, while Dr. K cleans a mouth wound on a boa constrictor so unpleasant it affects the entire clinic.

Tension is high as many critical patients visit the clinic. First, two sugar gliders are rushed in to receive treatment after getting tangled in a blanket and fighting their way out. Dr. Thielen checks out a newly adopted cockatiel that flew into a flytrap and has sticky material all over its feathers. Finally, a long-time bunny patient has an obstruction in her stomach that needs to be removed immediately.

Dr. K and her team are preparing for surgery on Bob the sulcata tortoise, who was brought in with a mass on his neck, likely a puncture wound caused by humping a stack of wood. At the same time, an emergency case is rushed into the treatment room. Shelby, a 9-year-old chinchilla, is bleeding from the mouth and the cause is unknown. Dr. K rushes to solve the case before the fragile animal loses too much blood. Meanwhile, Dr. Thielen takes on a mystery case involving a therapy chicken with a lame leg. The diagnosis leaves the owner faced with a heart-wrenching decision, while Mimi the pot-bellied pig is put to the weight loss test after being put on a diet.

A hedgehog attacked by a dog is brought into the clinic with a broken leg. Meanwhile, a 9-year-old chinchilla presenting with diarrhea becomes a life or death emergency.

It's business as usual at Dr. K's exotic animal E.R., until a stressed out Eurasian lynx is brought in for over-grooming and not eating. Dr. K suspects a large hairball to be at the root of the problem, and contemplates emergency surgery on the large cat. Dr. Thielen sees two emergency cases of her own, including a ball python that was brutally attacked by a feeder rat, and a rescued cockatiel that is in distress, trying to lay an egg. A lame baby chicken gets a new lease on life, while a recently neutered pot-bellied pig continues to heal and hopefully get rid of his "boy juices" smell.