Pickle must face her fear of big cats as she continues to impress Troy with her natural snake hunting talent. Bill and Tes hunt stumble on a rumored government testing facility and find all they can handle. Dusty recruits a new hunting partner with a snake phobia while Zak and Aaron battle pythons and the supernatural.

Troy Landry and Pickle witness just how far the pythons have spread. Zak and Aaron take on a whole new type of beast. Bill and Tess tackle some uninvited guests, while Dusty does what he can to prevent an early end to his python season.