17-year-old Brittanee Drexel suddenly disappears from spring break in Myrtle Beach. She leaves a friend's hotel and is never seen again. But the case comes alive when twisted and disturbing details start to emerge from a prison cell.

6-year-old Timmothy Pitzen vanishes after a three-day trip to waterparks and the zoo with his mom. In a terrifying twist, his mom is found dead in a motel room with a disturbing note by her side.

Infant Lisa Irwin was abducted from her crib in her family's Kansas, MO home in 2011. Her disappearance was discovered by her father Jeremy in the early morning of October 4, after coming home from his late-night job. Several cellphones are also missing from the house.

Three young brothers are reported missing the day after Thanksgiving; in a shocking twist, their father claims he gave them to an underground group, but investigators say his story doesn't add up.

After 7-year-old Kyron Horman's stepmother drops him off at a school science fair and takes a picture, the little boy is never seen again; his disappearance is one of the largest mysteries and investigations in Oregon's history.

Russell Dermond's headless body is found in the garage of his million-dollar lakefront mansion. His wife, Shirley, is found floating dead in the water, her ankles tethered with cinder blocks. One key piece of evidence still remains missing.