The Last Frontier follows U.S. Marshal Frank Remnick, the lone Marshal in charge of the quiet, rugged barrens of Alaska, whose jurisdiction is turned upside-down when a prison transport plane crashes in the remote wilderness, setting free dozens of violent inmates. Tasked with protecting the town he's vowed to keep safe, he begins to suspect the crash wasn't an accident, but the first step of a well-crafted plan with international political implications.