After a tragic accident, one of Joan's oldest friends is rushed to Minneapolis to be treated by her, forcing Amy to confront her about her illness; Richard and TJ find themselves at odds when they treat a tech bro who thrives on pushing boundaries.

Met with hostility upon his return, Richard looks to redeem himself while treating an overworked food delivery worker; Sonya and TJ enlist Jake's help with the delicate Joan situation; Amy and TJ take on the case of a medical malpractice lawyer.

While navigating the fallout from Katie's secret, Amy treats a critically ill patient with a dark one of her own. As Gina and Jake evaluate a world-class poker player, searching for the source of what may be a mental disorder, Jake is forced to hide the truth from Amy about Rachel's health scare. Sonya and TJ investigate their theory behind Joan's frequent absences. And Richard returns with a trick up his sleeve.

A shocking turn of events ensues when Amy and Jake treat an expectant mother injured during a robbery. Michael is challenged to open up when Katie's therapist invites him and Amy to a session. TJ and Sonya help Julie navigate a mysterious illness and an unexpected romance.

The race for Chief resident intensifies as Joan tasks Amy and Sonya with evaluating each other's case work. Amy tends to a politician with a disability whose dire health complications threaten to interrupt a crucial vote. Sonya struggles to find a solution to her combative patient's excruciating abdominal pain. Michael's parents come to town causing more family drama for him and Katie.

Charlie fights for his life at Westside with Hannah by his side. The Board launches an internal investigation into Brian Clark's resignation, putting everyone in the hot seat and motivating Amy to figure out what happened before the hospital can make her a scapegoat. A familiar face returns to Westside and Amy is not happy about it.

The search for Amy's hacker intensifies when the hospital finally brings in the FBI. Hannah, devastated by the death of her patient, works with Amy to treat a sick older man whose daughter believes has been poisoned. Meanwhile, Sonya and TJ examine middle school kids for scoliosis, and discover a child with a different ailment and a home situation that may've caused it to get much worse.

With the search underway to find out the truth about Amy's hacked accounts, she and Sonya butt heads while treating a homeless patient with a crush injury who was dumped in front of Westside Hospital. Jake and TJ help a distraught mother figure out why her daughter is in a coma. Hannah cares for a charming high school athlete, while working with Charlie to cover their tracks by infiltrating the hospital computer system. Unfortunately, those efforts result in major collateral damage.

At Jake's father's funeral, grief helps clarify his feelings for Amy; in a gripping flashback story, Jake's past intentions to leave Westside are revealed, along with the reason he decided to stay; Charlie goes too far with the plan to destroy Amy.

After receiving tragic news, Jake refuses to give up on a beloved patient, landing himself in conflict with several Westside surgeons; when Amy's neuro tests elicit memories of Danny, she pushes herself too far.

Amy and Gina, with an assist from Jake, team up to help a victim of domestic abuse; TJ finds himself in the spotlight when he, Sonya and Liz treat a social media influencer; Hannah and Charlie conspire to destroy Amy.

Amy treats a chaplain who helps her reconcile with the past; Michael is under investigation for his actions during the hostage crisis; TJ returns to work and treats a prisoner; Hannah's brother shows up with a plan.

A popular weight loss medication reveals the cracks in a couple's relationship; two sisters face an unexpected diagnosis.

An outdated medical proxy form creates tension between a patient's ex-husband and current partner; Amy, Jake and new intern Hannah investigate a college student's sudden blindness.

A patient forces Amy to confront the realities of medical tourism; TJ helps a veteran with his prosthetic; Joan drops a bombshell.

Amy grapples with having memories while treating a mother-to-be with a mysterious condition; Dr. Joan Ridley, Amy's mentor, visits Westside.

Amy's past comes back to haunt her when a desperate father sacrifices everything to secure his daughter's heart transplant.