Michael & Lincoln must handover Whistler to Susan so they can save LJ and Sofia's lives; Mahone seizes a golden opportunity; T-Bag shows Sona who's boss; a familiar face enters Sona as another leaves it in a body bag.

Michael and his fellow inmates make their break from Sona, but the escape doesn't go as planned for all of them.

Heavy rains force Michael to move up the escape timetable and break out of Sona that evening. Another inmate joins in on the escape, and T-Bag and Lechero form an alliance as Bellick hopes to form one with Mahone. Lincoln and Sucre help bring the lights down on Sona.

When Lechero loses his authority over Sona, Sammy causes Michael's escape plan to come crashing down. T-Bag pressures Bellick to one more fight that will likely be his last. Lincoln and Sucre plan an explosive end for Susan.

After raising the suspicions of the Panamanian Army, Michael sweats out solitary Sona-style while Bellick weathers the fight of his life. Susan sets her sights on Sucre as T-Bag schemes his way into the escape.

Susan takes the escape into her own hands, leaving Michael's life hanging in the balance; Lechero reveals a secret buried beneath Sona; Sofia uncovers more of Whistler's past; Mahone's freedom hinges on his testimony; and Lincoln and Sucre are targeted by The Company.

Everything goes wrong for Michael as he tries to create a diversion. Lincoln tries to outsmart Susan who has his son. Sucre offers his assistance to Lincoln.

When an inmate is found murdered, Whistler becomes the prime suspect and Michael must prove his innocence in order to save his life; Michael demands evidence from Susan that Sara is alive, or he will cancel the escape; Lincoln and Sofia monitor the guards' morning rituals; Mahone gets an offer that may get him a ticket out of Sona.

A new inmate enters Sona, unnerving Whistler and raising Michael's suspicions; Lincoln plans an ocean getaway with Sofia as Susan moves up the escape timetable; T-Bag tempts his fate with his latest attraction; and Sucre attempts to get the goods into Sona.

After his failed attempt to rescue LJ and Sara, Lincoln receives a deadly warning from The Company; Michael formulates an electrifying escape plan from Sona; Mahone is haunted by a face from the past; and T-Bag crawls up the ladder as Bellick lands in hot water with Lechero.

Determined to speak with Sara, Michael enlists T-Bag's help to get to the only phone in Sona: Lechero's; Lincoln attempts a daring rescue; Whistler comes clean to Michael, just as Mahone is tempted to fall back on a dirty habit; and Bellick makes an enemy while attempting to get back on his feet.

Michael races to find a hidden Whistler before Mahone; searching for clues outside the prison, Lincoln runs into an old friend and makes a new one; T-Bag slithers his way into Lechero's graces as the prisoners threaten a revolt due to the lack of agua (water).

The season opener finds Michael Scofield in Sona, a hellish and deadly Panamanian prison where a previous riot has forced all authority out and has left the prisoners in charge of their own lives (and deaths). With the fate of his loved ones hanging in the balance, Michael must to find Whistler, a mysterious fellow inmate hiding within the prison's sewer system, in order to break him out from a prison from which there is no way out. Meanwhile, Lincoln searches for a missing Sara and receives troubling news about LJ on "Orientacion."