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Michael's medical condition forces Sara to take him to the hospital, and Sucre and Lincoln get themselves into an explosive situation. Mahone has designs on the Company's architect while Agent Self meets with a surprising ally.
Wyatt gets a taste of his own medicine, and Mahone finds some resolution. T-Bag scrambles when the police investigate his missing co-worker while Gretchen gets cozy with a Company man. Michael's condition continues to worsen, and a team member makes the ultimate sacrifice while planning the underground break-in for Scylla.
Michael races against time and his ailing health to break into the Company headquarters to steal Scylla, but the break-in's success lies with Sucre. Gretchen dresses up for a meeting with the General and one final attempt to get the last card key. T-Bag must make a decision to leave his criminal ways for good.
The major storyline for the fourth season is about a team recruited by Homeland Security agent Don Self to obtain the Scylla. Although the team initially believes it to be The Company's "black book," it is later revealed to contain information on an advanced renewable power cell.