Michael's medical condition forces Sara to take him to the hospital, and Sucre and Lincoln get themselves into an explosive situation. Mahone has designs on the Company's architect while Agent Self meets with a surprising ally.

The search for Scylla comes to a shocking end as Sara takes a hostage, T-Bag and Gretchen have their last stand at Gate, and Michael and Lincoln come face-to-face with the General and are betrayed by one of their own.