Mary Mallon spreads typhoid fever wherever she goes, and Cleopatra's younger sister Arsinoe schemes her way in and out of power in Ancient Egypt.

Navy officer Douglas Hegdahl outwits his captors when he's taken as a POW in North Vietnam; Florence Nightingale revolutionizes the field of nursing.

Marina Raskova forms an all-women air force regiment to fight Nazis in World War II; smuggler James J. Andrews hijacks a Confederate train for the Union.

Martha Mitchell leaks the Watergate scandal to the press before Deep Throat does; the Citizen's Commission to investigate the FBI stages an epic break-in.

Forest service ranger Ed Pulaski saves 40 men from a forest fire; Ted Patrick rescues teenagers from the psychological grip of the Children of God cult.

Hedy Lamarr designs the first modern airplane wing, Eartha Kitt's activism provokes the ire of Lady Bird Johnson, and Alexis Pulaski's poodle becomes a huge star.

Lead Belly records songs with John Lomax that change the face of music; John Lennon and Yoko Ono almost get deported; Sam Cooke writes "A Change Is Gonna Come".

Larry Walters pilots a balloon-suspended lawn chair; Phineas Gage survives an iron rod to the brain; and the Greenbrier Ghost's testimony is used in court.

Colonial gossip columnist James Callender winds up dead; a Hollywood producer dies on a celebrity-filled yacht; Ken McElroy is murdered after terrorizing a Missouri town.

Journalist Maurine Dallas Watkins writes a play about Chicago's infamous Murderesses' Row; Mata Hari goes from exotic dancer to double agent during World War I.

John F. Kennedy's doctor administers him meth for his back pain; Dr. John C. Lilly takes LSD while studying the intelligence of dolphins.

People going to extremes for love, including a student who tunnels beneath the Berlin Wall, Edie Windsor topples the Defense of Marriage Act, and John Wojtowicz robs a bank to pay for his wife's gender reassignment surgery.

Bessie Coleman is America's first black woman pilot; the students of the Little Rock Nine integrate a high school following the Brown v. Board of Education decision.

Moses Fleetwood Walker faces racism in the 19th-century MLB; the Chicago White Sox are accused of intentionally losing the 1919 World Series; the Callaghan sisters inspire the film "A League of Their Own".

John Muir convinces Teddy Roosevelt to preserve Yosemite; journalist Marjory Stoneman Douglas fights to protect the Everglades; Native American activists occupy Alcatraz.

Will Ferrell and Seth Rogen star in this episode about how teenage writer Mary Shelley created her legendary novel, "Frankenstein".