Neela has recurring dreams about trying to save a girl with sickle cell anemia. In them she also goes to an attending interview and sees an old colleague, has conversations with Ray, welcomes Brenner back from Australia, and assists Gates and Banfield in trying to save a "dream runner" who jumped out of a window during his sleep.

Gates and Morris tend to an elderly man who was assaulted on the street. Sam's sister shows up unexpectedly. Brenner and Dubenko clash while treating a mother thought to have late stage cancer. Dr. Morgenstern returns to the ER to assist a former mentor who is seriously ill.