The docs are on double duty when Dr. Ross brings his daughter into the clinic. A dog is rushed to Dr. Lavigne after suffering multiple seizures and Dr. Blue performs a tricky surgery. The staff must tame a feisty feline patient.

Police rescue a turtle caught on fishing line and it's up to Dr. Ross to unhook him. Dr. Blue must wait for test results after performing dental surgery on a loveable dachshund, while Dr. Lavigne gives a stray cat first class treatment.
 

Dr. Lavigne does a not so routine surgery on a hermaphrodite dog that's both male and female. A bearded dragon is battling a skin disease that Dr. Ross must treat before it causes serious problems. Dr. Blue manages work and a big family move.

The docs head to the Renaissance Faire to tend to the birds of prey in need of the West Nile vaccine. Piper the peppy dachshund is not herself and Dr. Lavigne must perform surgery. Meanwhile, Dr. Ross treats Tesla the tortoise for a fractured beak.

Dr. Lavigne performs a doggy nose job to help a pug with bad breathing problems. Dr. Blue urgently treats Hardtime, a dog who's facing hard times battling heart disease. An opossum with a traumatic injury needs Dr. Ross's help.
 

A chicken is rushed to Dr. Ross after being attacked by a coyote. When a Great Dane mix has a seizure, Dr. Lavigne uncovers multiple issues. A surprise serenade at the clinic musically inspires Dr. Blue.

We follow three vets and their families as they begin new lives and careers in Houston. It's a big move to a big state, but they dream big, and they're determined to make this work -- for their families, and for the animals of Houston.

The doctors prepare to open a new clinic but are apprehensive about a promise they made to each other regarding the event. Dr. Ross tends to a frizzle hen's eye problem while Dr. Blue is alarmed by a bulldog's burst mammary gland.

From tiger rescues to a lifesaving and life-size tumor removal on a pit bull, best friend and vets Dr. Blue, Dr. Ross, and Dr. Lavigne have seen it all.