In the first three seasons, as Dr. Paul Weston continues to struggle with the aftermath of his divorce, he faces new emotional and physical challenges - including hand tremors that he fears might be the onset of Parkinson's Disease, which killed his father. Meanwhile, he takes on three challenging new patients and turns to a new therapist of his own.

In fourth season, the reimagining of the series is set in 2021 Los Angeles and brings a diverse trio of patients in session with the observant, empathetic Dr. Brooke Taylor to help navigate a variety of modern concerns. Issues such as the global pandemic and recent major social and cultural shifts are a backdrop to the work Brooke will undertake – all while she deals with complications in her own personal life.