Christina returns to the hospital and Tom must perform surgery on a friend. Elsewhere, Kelly experiences a game-changing moment; Bobbie and Steve contemplate an all-important change; Camille mulls over leaving for college.

As her daughter tries to comfort her with advice and wisdom, Christina makes seismic life decisions that affect her husband and Det. Renata. Meanwhile, Miles plans to bid adieu to James River.

Christina seeks therapy, where she discloses hard truths about her marriage, Det. Renata, her daughter and her own childhood. Meanwhile, Tom delicately tries to keep a friend's hopes alive while confirming a harsh diagnosis.

A new opportunity comes Christina's way; Camille and Miles mull over their future; Bobbie makes a mistake and may pay a steep price for it; friction mounts between Tom and Nick.

Christina and Nick team up to plan a birthday bash for Mama Renata. Meanwhile, Camille learns a seismic life lesson when she encounters Miles' wife; Bobbie throws a fund-raiser for the cancer lab; Morrissey's troubles hit a fever pitch.

Christina and Tom keep company with Miles' visiting children; internal-affairs snoop Jimmy Dupree continues to scrutinize Renata; Bobbie participates in an article about the hospital; Kelly and Dr. Marshall inch closer to one another.

Internal-affairs investigator Jimmy Dupree continues to snoop into an attack at the hospital and sharpens his focus on Renata. Meanwhile, the day of a health fair is tarnished by a possible bacteria outbreak; and recent developments haunt Morrissey.

Renata's mother falls ill, so he turns to Christina for help. Elsewhere, a pesky internal-affairs sleuth arrives at James River to investigate recent events; and Camille is offered a hospital job despite her flirty overtures toward Miles.

Recent events test Tom and Christina. Meanwhile, nursing responsibilities create friction between Bobbie and Christina; a flirty Camille tries to woo Tom's apprentice.

Christina and Tom's wedding day arrives, but the big event is marked by a bizarre turn of events. Meanwhile, Det. Nick Renata arrives to investigate an attack at the hospital; and Candy goes into labor.