Season 2 closes with a construction accident that causes an explosion, sparking crisis and chaos at the hospital. Elsewhere, Dr. Marshall pushes Ray's buttons regarding his feelings toward Candy; Bobbie and Steve offer truths about their pasts.

In the wake of a critical situation involving her daughter, Christina turns to Det. Nick Renata for help. Elsewhere, Kelly searches for a mourning mother's camera; Erin and Christina butt heads over Tom's career; and Steve is haunted by a past figure.

Christina teams up with a detective to locate Isabel, who goes on the lam after kidnapping her son from foster care. Elsewhere, Tom returns to surgery; and a hidden truth about Candy bubbles to the surface. 

Christina tries to treat an old friend but runs into insurance-company roadblocks. Meanwhile, Tom's blossoming relationship with Erin irritates Christina; tension grows between Christina and Camille; and Kelly reveals a hidden truth about herself.

A pregnant Afghan woman arrives for medical care after a fall, but her life hangs in the balance when language barriers interfere with treatment. Meanwhile, Tom anticipates going into surgery; Camille is caught in an embarrassing situation.

Tom recuperates from his car-accident injuries but faces the prospect of surgery. Meanwhile, twin sisters with serious kidney problems have an impact on Camille, and a sick child makes a wish to meet an athlete.

An ethical conflict rages when a death-row inmate arrives at the hospital for lifesaving treatment. And as Tom continues to deal with his car-accident injuries, Christina introspectively considers heating up their relationship.

When he sustains critical injuries in a car crash, Tom fears that he may never be able to perform surgery again. Meanwhile, Candy returns from her tour of duty in Afghanistan. And a child must disclose a hard truth about his grandmother to save her life.

Christina pays a visit to the ethics committee when she opposes the hospital's refusal to treat a heroin-addicted patient. Elsewhere, a mother reveals a game-changing secret to her adopted son; and Camille forges a bond with hospital worker Marcus.

With Richmond Trinity out of business, numerous staff members land employment at a decaying hospital in a run-down neighborhood. There, Christina and Bobbie clash with the nursing supervisor, and Tom must relinquish his administrative post.