Divorcee Lia is acting sister and her friends Beth and the sensible Kate nurses at St Margaret's hospital, along with their promiscuous friend Anji, a health care assistant. However Kate resigns after senior house officer Jamie has blamed her for his mistake, resulting in a patient's death, and she has publicly punched him. Beth gets her own back on young house officer Callum by putting a sedative in his drink when he is on call and Lia's daughter, who lives with her father, berates her for preferring the nurses' company to visiting her. Anji has a one night stand but tells the man in question she is terminally ill to avoid future dates.