Divorcee Lia is acting sister and her friends Beth and the sensible Kate nurses at St Margaret's hospital, along with their promiscuous friend Anji, a health care assistant. However Kate resigns after senior house officer Jamie has blamed her for his mistake, resulting in a patient's death, and she has publicly punched him. Beth gets her own back on young house officer Callum by putting a sedative in his drink when he is on call and Lia's daughter, who lives with her father, berates her for preferring the nurses' company to visiting her. Anji has a one night stand but tells the man in question she is terminally ill to avoid future dates.

Lia is alarmed to learn that her ex-husband Al and his new partner Sally are planning to move away with Emma and after she promises to see her daughter more the move is cancelled. When the wrong kidney is taken out of a patient Anji tumbles to the truth but Jamie tries to take the credit. As a result the patient is persuaded not to sue but Beth ends up a hundred pounds better off . Callum also makes a mistake whilst Kate, attending an anger management course, makes it clear she will never allow anybody to walk over her again.