The nurses feel sorry for new registrar Jane Salter, rumoured to be a Lesbian and thus on the receiving end of flak from male colleagues. Anji tries to offer her advice but when she is given the chance to train as a nurse and Jane tells her it was probably only down to an equal opportunities policy Anji feels betrayed and the nurses stitch Jane up at her welcome party. Kate befriends Ray, a morgue attendant with a strange sense of humour, whilst Beth is declared a local hero after diagnosing a patient with a heart condition as having Munchhausen's. However, when the patient is readmitted after drinking fabric conditioner, opinions of Beth change. Anji decides against taking up nursing training after Callum tells her he only became a doctor to please his father.

Beth goes after Paul, a wealthy and handsome medic who is being headhunted for a management post but there is one snag - he is married. Beth's aunt Pat is admitted to her ward with a foot infection and Beth goes out of her way to avoid her, the animosity between the two women being explained when Beth's cousin Kelvin turns up. Senior consultant McManus takes Callum under his wing, betting that he will beat a rival consultant's protégé at golf but too much concentration on the tournament leads to Callum making more mistakes on the ward. Kate meanwhile decides to give herself a glamorous make-over.

Lia is alarmed to learn that her ex-husband Al and his new partner Sally are planning to move away with Emma and after she promises to see her daughter more the move is cancelled. When the wrong kidney is taken out of a patient Anji tumbles to the truth but Jamie tries to take the credit. As a result the patient is persuaded not to sue but Beth ends up a hundred pounds better off . Callum also makes a mistake whilst Kate, attending an anger management course, makes it clear she will never allow anybody to walk over her again.

Subject to an upcoming arranged marriage Anji feels guilty that her future husband is keeping himself celibate for her and befriends a psychiatrist who has not had sex in years but, being Anji, such things do not last. With Kate gone Carl Jenkins is senior nurse on the ward and soon finds himself on the losing end of a series of practical jokes with the nurses. When he gets grabbed by an obese patient he files a complaint of sexual harassment, which blows his chances with Lia. Kate agrees to return if she is appointed staff nurse.

Divorcee Lia is acting sister and her friends Beth and the sensible Kate nurses at St Margaret's hospital, along with their promiscuous friend Anji, a health care assistant. However Kate resigns after senior house officer Jamie has blamed her for his mistake, resulting in a patient's death, and she has publicly punched him. Beth gets her own back on young house officer Callum by putting a sedative in his drink when he is on call and Lia's daughter, who lives with her father, berates her for preferring the nurses' company to visiting her. Anji has a one night stand but tells the man in question she is terminally ill to avoid future dates.