When a famous Civil War photographer arrives to take a town portrait, he is delayed by bickering, and Dr. Mike discovers he is going blind.

When one of Dr. Mike's patients dies and leaves behind an illegitimate child, Hank is forced to admit he is the boy's father.

Dr. Mike is forced to operate on Brian after he suffers a severe head injury; the townspeople argue over the construction of a new school.

Influenced by romance novels, Colleen develops a crush on Sully and endangers her life when she sets up a situation in which he must rescue her.

Dr. Mike is at odds with Matthew when he announces his decision to forgo a university education and marry Ingrid.

A lonely Dr. Mike believes the whole town feels sorry for her as she prepares to celebrate another birthday as an unmarried woman.

After Gen. Custer injures Cloud Dancing and sentences him to hang, Dr. Mike and Sully orchestrate his escape.

When Sully is beaten and left for dead by skinners who are slaughtering buffalo, Dr. Mike fears he may be paralyzed.

A thieving cowhand rides into town and quickly disappears after robbing Loren's store and leaving his sick baby with Dr. Mike.

When a medicine-show man arrives in town, selling an elixir he claims will cure anything, Dr. Mike becomes determined to prove him a fraud.

Dr. Mike threatens a wealthy mining baron when mercury from his mine contaminates the town's water supply and causes illness in the community.

Dr. Mike is suspicious when Charlotte's husband returns to the children he abandoned and tries to convince the town that he has changed.

A bitter Loren, who blames Sully for his daughter's death, tries to repossess Dr. Mike's cabin when he learns he still owns the deed.

Dr. Mike hires a retired gunslinger as sheriff to save the life of an orphaned immigrant who stole a cow to feed his starving family.

Dr. Mike's disapproving mother visits from Boston and finds her daughter's unconventional life on the frontier difficult to accept.

While trying to stave off an influenza epidemic, Dr. Mike falls prey to the deadly virus, leaving the town in jeopardy.

After her father dies, Mike leaves Boston for Colorado Springs, where she sets up practice and adopts three orphans.