When Sgt. McKay holds Sully responsible for the Dog Soldiers' attacks, he and Cloud Dancing escape to safer American Indian lands.

Defying government orders, Sully becomes a wanted man after he enters an American Indian reservation and helps Cloud Dancing escape.

When Brian's irresponsible behavior puts the town in danger, Sully must step in and begin acting like a real father to the boy.

Dr. Mike is shocked by her sister's liberal behavior and open relationship with Loren Bray after she joins the women's suffrage movement.

Horace attempts suicide after his wife leaves him, prompting Dr. Mike to send for her and their young daughter.

Brian takes a liking to visiting writer Walt Whitman, even when the townspeople shun Whitman over rumors of his alternative lifestyle.

Despite being wounded by two bank robbers, Sully works to free his wife, Brian and Katie when they are taken hostage by the desperate men.

Sully is humiliated when his wealthy friend develops feelings for Mike, and presents them with an offer of financial help.

Sully's wealthy friend Daniel falls for Mike and humiliates Sully with an offer of financial help.

Dr. Mike and Colleen recall past cases as part of a college course Colleen is taking; Andrew is overcome by a mysterious ailment. Features clips from previous episodes.

Kid Cole and Sister Ruth visit Dr. Mike at a difficult time in their marriage.

Dr. Mike's Uncle Theodore, a concert pianist, sees in Brian not only a talented musician, but his own dead son.

In a case of mistaken motivation, a judge sends Sully to prison after he is spotted with criminals bent on stopping the construction of a dam.

As Christmas approaches, Brian questions his faith when he learns that Dr. Mike cannot save the Rev. Johnson's sight.

Dr. Mike's practice is in jeopardy when her patients begin dying of a mysterious infection apparently contracted at the clinic.

Robert E. and Brian try to enroll Anthony in the all-white school; Jake and Hank open a hotel to rival Preston's.

A severe storm bears down on Colorado Springs, disrupting the arrival of Preston Lodge II and Dr. Mike's attempts to prepare a Thanksgiving dinner.

Dr. Mike, Sully and Matthew team up with a legendary marshal in order to nab the thieves who wounded Matthew during a bank robbery.

When a sick, old prospector wanders into town, Dr. Mike takes it upon herself to help reunite him with his family before it's too late after she tends to his ailments, one of which is the onset of dementia. However, she is unaware that Jake is the old man's son and he abandoned his family when Jake was still a child. After Brian announces that the prospector found a large nugget of gold nearby, Mr. Bray, Horace, and Hank catch gold fever.

Jake and Preston each want Mike's mayoral endorsement, until she is jailed for treating a fugitive Indian.

Sully gets an offer to survey the newly created Yellowstone National Park; Brian's first date; Dorothy teaches Cloud Dancing ballroom steps.

A Latin American woman rebuffs Dr. Mike's attempts at friendship; the Rev. Johnson searches for a teacher to take his place.

The appearance of renowned singer Gilda St. Clair tempts Colleen to leave college and travel the world instead.

A malpractice suit prevents Dr. Mike from practicing medicine, leaving the reluctant Dr. Cook in charge.

Dr. Mike finds the stresses of being a wife, mother and career woman too much and contemplates turning her practice over to Dr. Cook.

Robbers wreck a train carrying Sully and Cloud Dancing; Andrew is reluctant to return the practice to Dr. Mike.