It is the vampire apocalypse and Yuu wants to avenge his brother. To do this Yuu will have to learn many new skills. On his adventure he meets many new people such as Shinowa and many more.

The survivors of the Moon Demon Company get to the rendezvous point, only to find out that their orders are to "standby." Enraged, they decide to ignore the orders to save Guren, when Kureto appears. Apparently, Kureto has something else on the agenda.

Yu and Mika are finally reunited, but the injuries Mika had sustained from fighting the Demon Company threatens his life. Determined to keep Mika alive, Yu tries to persuade Mika into drinking his blood... Even if it means Mika will become a true vampire.

The power of angels forces Yu to stay alive, and Asuramaru lures him from their power. Mika waits for the Moon Demon Company and charges in to rescue Yu.

Shinoa's squad goes to save Guren, but unfortunately, they run out of time. Reluctantly, they leave him behind and retreat, but Yu just cannot bring himself to do that. Instead, he takes more of the Curse Stimulant Pills to go save Guren himself.

Guren, Shinoa, and Narumi squads arrive at the city hall and see the hostages. Knowing it's a set-up, they still decide to go save the hostages, but Guren and Shinya is way over their head with Crowley, as they struggle just to run away from him.

The Shinoa squad re-learns the hard cold fact that it's very possible to lose comrades, but there's no time to mourn. They must move on to go rescue the hostages. Right after their departure, Mika and the other vampires arrive to Nagoya as well.

Shinoa and Narumi Squads discuss their mission to exterminate Fifteenth Progenitor Lucal Wesker. Meanwhile, Shinya and Yoichi wait from their sniping point. Underground, Ichinose Squad struggles to defeat Nineteenth Progenitor Mel Stefano.

Shinoa Squad travels to the Ebina rest stop but their squad arrives late. As punishment, Guren, Mito, and Shinya fight against Shinoa Squad. Elsewhere, Mika and Lacus collect stray human children as a gift for vampires in Nagoya.

Shinoa Squad meets, and Kureto Hiragi and Guren Ichinose do the same. Kureto announces his plan to attack and wipe out ten noble vampires in Nagoya before the vampires bring their main army down on Japan in one month.

Yu begins the next step of his training and battles against Asuramaru. Ferid discusses the battle at Shinjuku. Kimizuki struggles in battle against Kiseki-o and faces memories where he was told to kill his sister.

Kureto Hiragi summons Yu to ask him about a vampire spy while torturing some friends to make him tell the truth.